Bisphosphonate (Fosamax, Actonel, Boniva, Didronel, Aredia and Skelid)
Use: Osteoporosis treatment
Issue: Can cause osteonecrosis of the jaw, a condition that results in chronic pain and disfigurement and is difficult to treat; long bone fractures; and esophageal cancer.
FDA Action/recommendation: This news came out in 2008 with an FDA warning. However, on 3111/2010, the FDA notified healthcare professionals and patients that at this point, the data reviewed have not shown a clear connection between bisphosphonate use and a risk of atypical subtrochanteric femur fractures.
Company: Fosamax (Merck); Actonel (Proctor and Gamble); Boniva (GlaxoSmithKline and Roche); Didronel (UTD); Aredia (Novartis); and Skelid (UTD).